1/2: I'm not too old but I never thought I'd see a believable #cyclin-targeting drug in my lifetime.
Kudos to the effort it took to make this peptide look more like a small molecule and we'll see what happens in the clinic.
pubs.acs.org/doi/10.1021/ac…
Orally Bioavailable Cyclin A/B RxL Inhibitors: Optimization of a Novel Class of Macrocyclic...
Cyclins A and B bind and activate their cognate cyclin-dependent kinase (CDK) to regulate progression through the S and G2/M phases of the cell cycle, respectively. Cyclins recruit substrates and...
From pubs.acs.org 1
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