Epigenetics Update - Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders bit.ly/3ObNmzE #Epigenetics #Chromatin #Polycomb #Neurodevelopment --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB Chen Davidovich/Omer Gilan (Monash University) in Nat Cell Biol #Epigenetics #DOT1L #Polycomb --- Gain deeper insights into gene regulation; epigenometech.com

Check this new work on BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies biorxiv.org/content/10.648…

RESEARCH PAPER: Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression By Bonnet et al., and Jürg Müller ➡️ genesdev.cshlp.org/content/40/1-2… @MPI_Biochem #polycomb #histone #chromatin #drosophila

Epigenetics Update - Widespread association of Polycomb complex–deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation bit.ly/4rw5p2I #Epigenetics #Polycomb --- Gain deeper insights into gene regulation; epigenometech.com

RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants By Deevy et al., Eric Conway and Adrian Bracken @conwayer1 @adrianbracken ➡️ genesdev.cshlp.org/content/39/21-… #weaversyndrome #ezh2 #polycomb #mutation #epigenetics #congenitaldisorder #onthecover

Epigenetics Update - VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing bit.ly/4p0x6Qb #Epigenetics #Polycomb #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation bit.ly/45A6DB9 #Epigenetics #Polycomb #Chromatin --- Gain high-res epigenetic insights at epigenometech.com

Glad to participate in @eLife @eLifeCommunity study led by Luis G. Palma @BigSpinLab @HMar_research showing how non-canonical role for IκBα / NF-κB in #chromatin #histone #polycomb regulation shapes embryonic #stemcell #pluripotency and differentiation. elifesciences.org/reviewed-prepr…

Epigenetics Update - CRAMP1 drives linker histone expression to enable Polycomb repression bit.ly/44fy7v8 Iva A. Tchasovnikarova (University of Cambridge) reproting in Mol Cell #Epigenetics #Polycomb --- Empower your research at epigenometech.com

Polycomb proteins don’t just compact chromatin—they sculpt its architecture across scales. Explore how new imaging and 3D genome tools reveal their role in modulating chromatin dynamics and domain segregation. #Chromatin #Polycomb #GeneRegulation #COSB sciencedirect.com/science/articl…

We hypothesize that these temperature-dependent dynamics alter the #chromatin structure from a modality active for #transcription to a state that can be #Polycomb silenced.

Epigenetics Update – “Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1” bit.ly/4hKTBVw #Epigenetics #Chromatin #Polycomb --- Gain deeper insights into gene regulation with epigenome.us

Epigenetics Update – “H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos” bit.ly/4ehKcC4 #Epigenetics #HisMods #Polycomb --- Perfect for cancer, immunology, and aging studies: epigenome.us

Epigenetics Update – “DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency” bit.ly/3YA4sdn #Epigenetics #Polycomb #Pluripotency --- Perfect for cancer, immunology, and aging research; find out more at epigenome.us

Epigenetics Update – "Activation of automethylated PRC2 by dimerization on chromatin" bit.ly/4dzgIz9 #Epigenetics #Polycomb #HisMods --- Empower your research with high-res epigenetic insights! Find out more at epigenome.us.