Mesut Kahraman
Mesut Kahraman @0vigilante ·
تريد تخفيض! كُـود كوبِون خـِصم Voucher حائل 🛁💪 ⎐نون⎐ ⊵KW44⊴ ⎐باث▬اند▬بودي⎐ ⎐ADPE⊴ ⊴6ستريت⎐6 ستريت⎐ ⎐EB1⊴ Pastel Sea ^^ nGnkM
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anyep
anyep @yanuarmardianto ·
Duit pajek e dinggo kreak” kyo ngne ra cetho blass
Ken Hans Ken Hans @kenhans03 ·
Seorang YouTuber dan praktisi IT, David Alfa Sunarna, mengkritik website PT Agrinas Pangan Nusantara setelah melakukan review di kanal YouTube miliknya. Ia menilai tampilan dan pengelolaan situs tidak mencerminkan perusahaan BUMN yang mengelola dana besar. Tim media juga t sempat tidak bisa diakses dan diduga menggunakan Canva embed.  Itu namanya efesiensi bang... 😂🫢
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Sthu_M
Sthu_M @SthuM87 ·
Big brother we done with votings ne?ngne verse nawe as iPaprika, kphela nesingisi manje ngcela kukbona bhuti #justice for us baba
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Colton Williams
Colton Williams @colton91986 ·
Of course the second I sold $NGNE at $21.41, it’s up to the moon now! 💀 I'm actually smooth brain, biggest L of 2025. Never selling again (lying).
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mywaa..🐈
mywaa..🐈 @emyrakheidar ·
Replying to @emyrakheidar
bayangno wingi ak mbuka twitter kyk ngne bendino… ky ndelok bokep dek tv 😔9
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Joseph Cole
Joseph Cole @JosephCole31937 ·
Of course the second I sold at $21.41, NGNE shoots to the moon! I'm actually smooth brain 🤡. Biggest L of 2025—never selling again (lying).f
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🌚
🌚 @itsdiffxxa ·
Kemaren makan bareng tp tak mintain no rek buat bayar makananku malah ga dibales anjer😭 wong kok apikane kyo ngne
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aurora
aurora @aethersya ·
Kl sm2 bisa jaga komitmen ok si, tp lek kyk pcr ku ngne jelase gaono kabar selingkuhane onk seng enyar 😭
ay ay @cegilku ·
mau pacaran tapi yang engga ribet harus ngabarin 24/7.
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Anake_Mama🦄
Anake_Mama🦄 @__AlAdim__ ·
Replying to @sbyfess
@sbyfess Waduhh dari bnyk komen kok bnyk yg ga percaya Yoo?? Padahal jelas perintah e onk ng surah An-Nur ayat 32. Wahh keimanan seng Islam Iki perlu ditanyakan rekk nek kyk ngne carane. Mosok tuhane Dewe seng ngomong tpi masih ragu atau malah ga percoyo ambk maha seng ngasih rezeki??
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handy
handy @kwhandy ·
Replying to @icaakep
@icaakep tp kui tampilane wes makanan berat dudu jajan mneh:( tp bundle makanan berat ngne ki sekali metu 1 spot opo beberapa spot? ngeri jg yo lek iso smpe bbrp spot
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Anake_Mama🦄
Anake_Mama🦄 @__AlAdim__ ·
Replying to @sbyfess
@sbyfess Kureng peka sih lebih tepatnya, Soale nek POV ku cowo ya tak bawain sesuatu opo Mane wayae lebaran ngne Iki
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aurora
aurora @aethersya ·
Lanangan ku yo kyk ngne, wes ra teges gawenane selingkuh mbe micet tros ncen wong aneh
🦈 SUROBOYOFESS 🐊 🦈 SUROBOYOFESS 🐊 @sbyfess ·
“aku bingung” “aku gatau” “pusing aku” “terserah kamu” oalah -rek lanangan opo iki jan ra teges blas
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mike
mike @mike98572986 ·
$clpt $ngne I think I might have found the missing link, I was concerned that usually clearpoint is not involved with ICV but check this out pmc.ncbi.nlm.nih.gov/articles/PMC12… GS-100 or vehicle administration i.c.v. administration of GS-100 in wild-type and Ngly1−/− rats was conducted on PND 27–29, as previously described.6 A ClearPoint SmartFlow cannula (ClearPoint Neuro, Solana Beach, CA) was carefully lowered into place, and either GS-100 or vehicle (0.001% Poloxamer 188 in sterile phosphate-buffered saline [PBS]) was infused into the lateral ventricle. So now we connect Daniel Curry to Grace Science using ICV. NGLY-1 is Grace Science. It’s not likely he creates a program, uses clearpoint for Aadc first, doesn’t use Clearpoint for Rett for ICV and now does Grace Science for clearpoint for ICV. Logically doesn’t really make sense. I think the probability of Neurogene’s rett program being clearpoint just went up. My last post on this topic referenced this, I didn’t connect the ICV and Grace connection, I connected the Grace connection but I didn’t fully grasp that they are using ICV. My biggest concern has always been that Clearpoint typically isn’t involved in ICV. Which clearly they are on a program directly created from the same guy that did aadc, rett and Ngly Seems highly unlikely that a program created out of his lab wouldn’t be using Clearpoint in this sequence of events. See bottom 2 paragraphs. Daniel Curry new disclosure Daniel Curry: Advisory board (NeuroPace), Consultant (Clearpoint Neuro), PTC Therapeutics) Neurogene and Grace Scientific Clearpoint works with Neuropace, He is a consultant for clearpoint He was a big part in the aadc trial, he did the first commercial surgery in the US for aadc Grace Science is using our cannula and is doing the delivery as “ICV” Now that is 4 out of 4, he did the first procedures of Neurogene.. Which gives us a decent probability of being our program, obviously no guarantees but everything else that we know about this program, the probability just went up again that we have a 2nd BTD, Dr. Curry helped develop the Texas Children’s Intracerebral Gene Therapy Program with investigations into intraputamenal gene therapy for AADC deficiency, as well as investigations into gene therapy for Rett syndrome and NGLY-1 deficiency. Dr. Curry is also Director of the Neuroinfusion Service at Texas Children’s, conducting intracerebral enzyme replacement therapy in Batten’s disease and other neurodegenerative diseases.   “With these exciting advancements in gene delivery and surgical precision, we can not only treat the root cause of diseases in the brain, but hopefully reverse them,” said Dr. Curry. “This will make a life-changing difference for so many patients.”
Preclinical pharmacology and safety studies to support an AAV9 NGLY1 gene therapy clinical trial...

GS-100 is an AAV9 gene replacement therapy for the treatment of N-glycanase 1 (NGLY1) deficiency, an ultra-rare, recessive disorder characterized by developmental delay, intellectual disability,...

From pmc.ncbi.nlm.nih.gov
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