NK and T cells with metabolite-sensing receptors, like GPR183, GPR84, GPR34 & GPR18, show promise in targeting breast & ovarian tumors. PMID:41872506, Nat Immunol 2026, @NatImmunol @OTSociety @NAR_Open doi.org/10.1038/s41590… #AI #Pharma #BioMed #RNA #ASHG #ESHG
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors
Nature Immunology - Here the authors use CRISPR activation screens to identify metabolite-sensing receptors that affect lymphocyte targeting and infiltration of tumors and engineer CAR T and CAR NK...
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