The efficient accumulation and uniform distribution of nanomedicine within tumors are critical for achieving therapeutic outcomes. However, conventional medical imaging technologies struggle to...

Small-molecule drug discovery requires balancing potency, selectivity, solubility, safety, and synthetic feasibility, among other interdependent properties. Yet most computational workflows address...

Organophosphorus compounds (OPCs) are widely applied in diverse industries, yet their continuous release across the full life cycle poses significant risks to human health and ecosystems. Current...

In vivo multiple-enzyme cascades have attracted considerable interest for their ability to provide a native microenvironment that supports enzymatic activity and membrane protein function. This...

The rapid advancement of photorechargeable batteries is driven by the need for efficient solar energy utilization, with photoassisted lithium–sulfur batteries (PALSBs) emerging as strong contenders...

Polyethylene terephthalate (PET) is a widely used plastic due to its durability and adaptability; however, its resistance to natural degradation has led to severe accumulation in the environment....

Long-Tea-CLIP (Contrastive Language-Image Pre-training) presents a multimodal AI framework that integrates visual, metabolomic, and sensory knowledge to grade green tea across appearance, soup...

A key challenge in hydrogen sulfide (H2S) detection is developing gas sensors that concurrently achieve high sensitivity, excellent selectivity, and low-cost fabrication, critical for industrial...

Metabolic pathway design is a fundamental aspect of metabolic engineering, playing a crucial role in the microbial synthesis of high-value compounds. While metabolic engineers recognize the prevale...

The escalating crisis of multidrug-resistant bacteria demands a new generation of antibiotics. Glycocin F (GccF), a potent bacteriocin, is a promising candidate, but its function hinges on unique...

Currently, more than 350,000 chemicals and chemical mixtures have been registered for global production and use, and they are inevitably released into global near-coastal environments during their...

Nitrogen fertilizer, as an indispensable input in crop production, has played a crucial role in enhancing crop yields. However, the associated cropland nitrogen runoff has significantly intensified...

Fourier-transform infrared (FTIR) spectroscopy is a widely adopted technique for microplastic (MP) identification due to its molecular sensitivity and nondestructive nature. However, many FTIR–mach...

Cellulose is one of the most abundant natural renewable polymers. Its wide availability, biocompatibility, and biodegradability enable broad applications in papermaking, textiles, biomedical materi...

In this study, we utilized a high-performance soaking system of protein kinase A (PKA) to perform a crystallographic screening of a natural product-like fragment library. We resolved 36 fragment-bo...

As generative artificial intelligence (AI) tools such as large language models (LLMs) become widespread, they are increasingly finding applications in chemical sciences. Although LLMs have achieved...